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Article

Structural basis for Spt5-mediated recruitment of the Paf1 complex to chromatin.

Proceedings of the National Academy of Sciences of the United States of America - 22 Oct 2013

Wier Adam D, Mayekar Manasi K, Héroux Annie, Arndt Karen M, VanDemark Andrew P

Abstract excerpt

Polymerase associated factor 1 complex (Paf1C) broadly influences gene expression by regulating chromatin structure and the recruitment of RNA-processing factors during transcription elongation. The Plus3 domain of the Rtf1 subunit mediates Paf1C recruitment to genes by binding a repeating domain within the elongation factor Spt5 (suppressor of Ty). Here we provide a molecular description of this interaction by...

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Identifiers

PMID: 24101474
DOI: 10.1073/pnas.1314754110
PMCID: PMC3808610

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