Article
The transcriptional co-activator proteins p300 and CBP stimulate adenovirus E1A conserved region 1 transactivation independent of a direct interaction.
FEBS letters - 1 Sept 1997
Mannervik M, Akusjärvi G
Abstract excerpt
p300 and CBP are two related transcriptional co-activator proteins required by many cellular transcription factors for activity. The adenovirus E1A protein binds p300 and CBP through its amino-terminus and conserved region (CR) 1. Fusing CR1 to a heterologous DNA-binding domain creates a potent t...
Topics
- Adenovirus E1A Proteins
- CREB-Binding Protein
- Chloramphenicol O-Acetyltransferase
- Escherichia coli
- Gene Expression
- Genes, Reporter
- HeLa Cells
- Humans
- Mutation
- Nuclear Proteins
- Protein Binding
- Recombinant Fusion Proteins
- Trans-Activators
- Transcription Factors
- Transcription, Genetic
- Transcriptional Activation
- Transfection