Article
An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity.
Molecular and cellular biology - 1 Apr 2007
Stankovic-Valentin Nicolas, Deltour Sophie, Seeler Jacob, Pinte Sébastien, Vergoten Gérard, Guérardel Cateline, Dejean Anne, Leprince Dominique
Abstract excerpt
Tumor suppressor HIC1 (hypermethylated in cancer 1) is a gene that is essential for mammalian development, epigenetically silenced in many human tumors, and involved in a complex pathway regulating P53 tumor suppression activity. HIC1 encodes a sequence-specific transcriptional repressor containing five Krüppel-like C(2)H(2) zinc fingers and an N-terminal BTB/POZ repression domain. Here, we show that endogenous...
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