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Article

A two-protein strategy for the functional loading of a cellular replicative DNA helicase.

Molecular cell - 1 Apr 2003

Velten Marion, McGovern Stephen, Marsin Stéphanie, Ehrlich S Dusko, Noirot Philippe, Polard Patrice

Abstract excerpt

The delivery of a ring-shaped hexameric helicase onto DNA is a fundamental step of DNA replication, conserved in all cellular organisms. We report the biochemical characterization of the bacterial hexameric replicative helicase DnaC of Bacillus subtilis with that of the two replication initiation proteins DnaI and DnaB. We show that DnaI and DnaB interact physically and functionally with the DnaC helicase and...

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Source

Identifiers

PMID: 12718886
DOI: 10.1016/s1097-2765(03)00130-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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