Article

Assessment of the Role of NOGO Gene Block in Enhancing the Neuro-regenerative Effect of Mesenchymal Stem Cells.

2021-01-05

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Amyotrophic Lateral Sclerosis (ALS) is a fatal disease. Mesenchymal stem cells (MSCs) have a therapeutic potential in neuronal diseases, factors as NOGO-A limit axonal regeneration. In this study, gene silencing was used to suppress Nogo-A expression in MSCs to enhance its neuro-regenerative role.<bold> </bold><bold>Methods:</bold> mouse models of motor neuron d...

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Literature Corpus work: b430dc58-2403-51ae-999c-5dde72337b65
DOI: 10.21203/rs.3.rs-137171/v1

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