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Keratin Mutation in Transgenic Mice Predisposes to Fas But Not Tnf–Induced Apoptosis and Massive Liver Injury

1 May 2003

Abstract excerpt

Hepatocytes express keratins 8 and 18 (K8/18) as their only cytoskeletal intermediate filament (IF) proteins, and K8/18 mutations predispose their carriers to liver cirrhosis. Transgenic mice that overexpress mutant human K18 (Arg89-->Cys [R89C]) develop mild chronic hepatitis, hepatocyte fragility, keratin filament disruption, and increased susceptibility to drug-induced liver injury. K18 is a major caspase...

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PMID: 12717381
DOI: 10.1053/jhep.2003.50181

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