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Article

PKC412 normalizes mutation-related keratin filament disruption and hepatic injury in mice by promoting keratin-myosin binding.

Hepatology (Baltimore, Md.) - 1 Dec 2015

Kwan Raymond, Chen Lu, Looi Koksun, Tao Guo-Zhong, Weerasinghe Sujith V, Snider Natasha T, Conti Mary Anne, Adelstein Robert S, Xie Qing, Omary M Bishr

Abstract excerpt

UNLABELLED: Keratins, among other cytoskeletal intermediate filament proteins, are mutated at a highly conserved arginine with consequent severe disease phenotypes due to disruption of keratin filament organization. We screened a kinase inhibitor library, using A549 cells that are transduced with a lentivirus keratin 18 (K18) construct, to identify compounds that normalize filament disruption due to K18 Arg90Cys...

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Identifiers

PMID: 26126491
DOI: 10.1002/hep.27965
PMCID: PMC4681638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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