Article
PP2 protects from keratin mutation-associated liver injury and filament disruption via SRC kinase inhibition in male but not female mice.
Hepatology (Baltimore, Md.) - 1 Jan 2023
Li Pei, Maitra Dhiman, Kuo Ning, Kwan Raymond, Song Yang, Tang Weiliang, Chen Lu, Xie Qing, Liu Li, Omary M Bishr
Abstract excerpt
BACKGROUND AND AIMS: Hepatocyte keratin polypeptides 8/18 (K8/K18) are unique among intermediate filaments proteins (IFs) in that their mutation predisposes to, rather than causes, human disease. Mice that overexpress human K18 R90C manifest disrupted hepatocyte keratin filaments with hyperphosphorylated keratins and predisposition to Fas-induced liver injury. We hypothesized that high-throughput screening will...
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