Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models.

Gastroenterology - 1 Apr 2008

Strnad Pavel, Tao Guo-Zhong, Zhou Qin, Harada Masaru, Toivola Diana M, Brunt Elizabeth M, Omary M Bishr

Abstract excerpt

BACKGROUND & AIMS: Keratins 8 and 18 (K8/K18) are important hepatoprotective proteins. Animals expressing K8/K18 mutants show a marked susceptibility to acute/subacute liver injury. K8/K18 variants predispose to human end-stage liver disease and associate with fibrosis progression during chronic hepatitis C infection. We sought direct evidence for a keratin mutation-related predisposition to liver fibrosis using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbon Tetrachloride
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Mice, Transgenic

Share to Mutation

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 18395095
DOI: 10.1053/j.gastro.2008.01.035
PMCID: PMC2692280

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models.PMID 18395095Read ↗

Keratin mutation primes mouse liver to oxidative injury.Semantic proximity Read ↗

Keratin Mutation in Transgenic Mice Predisposes to Fas But Not Tnf–Induced Apoptosis and Massive Liver InjurySemantic proximity Read ↗

Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies.Semantic proximity Read ↗

Keratin 18 overexpression but not phosphorylation or filament organization blocks mouse Mallory body formation.Semantic proximity Read ↗

Keratin 8 mutations in transgenic mice predispose to lung injury.Semantic proximity Read ↗

Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations.Semantic proximity Read ↗

Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse model.Semantic proximity Read ↗

PKC412 normalizes mutation-related keratin filament disruption and hepatic injury in mice by promoting keratin-myosin binding.Semantic proximity Read ↗

Susceptibility to hepatotoxicity in transgenic mice that express a dominant-negative human keratin 18 mutant.Semantic proximity Read ↗

The Genetic Architecture of Carbon Tetrachloride-Induced Liver Fibrosis in Mice.Semantic proximity Read ↗

High Keratin 8/18 Ratio Predicts Aggressive Hepatocellular Cancer PhenotypeSemantic proximity Read ↗

Prevalence of genetic variants of keratins 8 and 18 in patients with drug-induced liver injury.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.