Mutation of a major keratin phosphorylation site predisposes to hepatotoxic injury in transgenic mice.

doi:10.1083/jcb.143.7.2023

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Article

Mutation of a major keratin phosphorylation site predisposes to hepatotoxic injury in transgenic mice.

The Journal of cell biology - 28 Dec 1998

Ku N O, Michie S A, Soetikno R M, Resurreccion E Z, Broome R L, Omary M B

Abstract excerpt

Simple epithelia express keratins 8 (K8) and 18 (K18) as their major intermediate filament (IF) proteins. One important physiologic function of K8/18 is to protect hepatocytes from drug-induced liver injury. Although the mechanism of this protection is unknown, marked K8/18 hyperphosphorylation o...

Topics

3T3 Cells
Actin Cytoskeleton
Amino Acid Substitution
Animals
Chemical and Drug Induced Liver Injury
Genetic Predisposition to Disease
Griseofulvin
Hepatectomy
Humans
Intermediate Filaments
Keratins
Liver Regeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Transgenic

Microcystins

Okadaic Acid

Peptides, Cyclic

Phosphorylation

Source

Open in PubMed Open full text

Identifiers

PMID: 9864372
DOI: 10.1083/jcb.143.7.2023
PMCID: PMC2175212

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9864372-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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