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Article

Mutation of a major keratin phosphorylation site predisposes to hepatotoxic injury in transgenic mice.

The Journal of cell biology - 28 Dec 1998

Ku N O, Michie S A, Soetikno R M, Resurreccion E Z, Broome R L, Omary M B

Abstract excerpt

Simple epithelia express keratins 8 (K8) and 18 (K18) as their major intermediate filament (IF) proteins. One important physiologic function of K8/18 is to protect hepatocytes from drug-induced liver injury. Although the mechanism of this protection is unknown, marked K8/18 hyperphosphorylation occurs in association with a variety of cell stresses and during mitosis. This increase in keratin phosphorylation...

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Identifiers

PMID: 9864372
DOI: 10.1083/jcb.143.7.2023
PMCID: PMC2175212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutation of a major keratin phosphorylation site predisposes to hepatotoxic injury in transgenic mice.PMID 9864372Read ↗

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Mutation of caspase-digestion sites in keratin 18 interferes with filament reorganization, and predisposes to hepatocyte necrosis and loss of membrane integrity.Semantic proximity Read ↗

Keratin Mutation in Transgenic Mice Predisposes to Fas But Not Tnf–Induced Apoptosis and Massive Liver InjurySemantic proximity Read ↗

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