Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Keratin mutation primes mouse liver to oxidative injury.

Hepatology (Baltimore, Md.) - 1 Mar 2005

Zhou Qin, Ji Xuhuai, Chen Lixin, Greenberg Harry B, Lu Shelly C, Omary M Bishr

Abstract excerpt

Mutation of the cytoskeletal intermediate filament proteins keratin 8 and keratin 18 (K8/K18) is associated with cirrhosis in humans, whereas transgenic mice that overexpress K18 Arg89-->Cys (R89C) have significant predisposition to liver injury. To study the mechanism of keratin-associated predi...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Profiling
Share to Glutathione
Share to Keratins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver Cirrhosis

Share to Mice, Transgenic

Share to Oxidation-Reduction

Source

Identifiers

PMID: 15726665
DOI: 10.1002/hep.20578

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15726665-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Keratin mutation primes mouse liver to oxidative injury.PMID 15726665Read ↗

Keratin Mutation in Transgenic Mice Predisposes to Fas But Not Tnf–Induced Apoptosis and Massive Liver InjurySemantic proximity Read ↗

Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models.Semantic proximity Read ↗

Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies.Semantic proximity Read ↗

Keratin 18 overexpression but not phosphorylation or filament organization blocks mouse Mallory body formation.Semantic proximity Read ↗

Mutation of caspase-digestion sites in keratin 18 interferes with filament reorganization, and predisposes to hepatocyte necrosis and loss of membrane integrity.Semantic proximity Read ↗

Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse model.Semantic proximity Read ↗

Susceptibility to hepatotoxicity in transgenic mice that express a dominant-negative human keratin 18 mutant.Semantic proximity Read ↗

Keratin 8 mutations in transgenic mice predispose to lung injury.Semantic proximity Read ↗

High Keratin 8/18 Ratio Predicts Aggressive Hepatocellular Cancer PhenotypeSemantic proximity Read ↗

Mutation of a major keratin phosphorylation site predisposes to hepatotoxic injury in transgenic mice.Semantic proximity Read ↗

Keratins as susceptibility genes for end-stage liver disease.Semantic proximity Read ↗

Keratin 18-deficiency results in steatohepatitis and liver tumors in old mice: A model of steatohepatitis-associated liver carcinogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.