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Article

Keratin 8 mutations in transgenic mice predispose to lung injury.

Journal of cell science - 1 Aug 2021

Kim Sujin, Lim Younglan, Lee So-Young, Yoon Han-Na, Yi Hayan, Jang Kwi-Hoon, Ku Nam-On

Abstract excerpt

Keratin 8 (K8) is the cytoskeletal intermediate filament protein of simple-type epithelia. Mutations in K8 predispose the affected individual and transgenic mouse to liver disease. However, the role of K8 in the lung has not been reported in mutant transgenic mouse models. Here, we investigated the susceptibility of two different transgenic mice expressing K8 Gly62-Cys (Gly62 replaced with Cys) or Ser74-Ala...

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Identifiers

PMID: 34342355
DOI: 10.1242/jcs.250167

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