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Evaluating the genetic toxicology of DNA-based products using existing genetic toxicology assays.

Mutagenesis - 1 May 2003

Smith Catherine C, Lynch Anthony M, Gooderham Nigel J

Abstract excerpt

Unlike the development of drugs based on small chemical entities there are no conventional regulatory toxicity studies established for DNA-based products. As the potential for insertional mutagenesis is of particular concern for gene therapy, we have investigated the mutagenicity of model non-viral DNA-based products at the HPRT locus in Chinese hamster V79 cells. Cultures were transfected with a pL3112BSKS...

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PMID: 12714691
DOI: 10.1093/mutage/18.3.259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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