Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Performance of the in vitro transgene mutation assay in MutaMouse FE1 cells: Evaluation of nine misleading ("False") positive chemicals.

Environmental and molecular mutagenesis - 1 Oct 2017

Maertens Rebecca M, Long Alexandra S, White Paul A

Abstract excerpt

The screening of chemicals for the protection of human health and the environment requires the assessment of genetic toxicity. However, existing, internationally-accepted in vitro mammalian genotoxicity tests have been criticized for their low specificity (i.e. high frequency of "false" or "misleading" positive results for compounds that are negative in vivo). An in vitro transgene mutation assay has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Count
Share to DNA Damage
Share to False Positive Reactions

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutagenicity Tests

Share to Mutagens

Share to Mutation

Source

Identifiers

PMID: 28843037
DOI: 10.1002/em.22125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Performance of the in vitro transgene mutation assay in MutaMouse FE1 cells: Evaluation of nine misleading ("False") positive chemicals.PMID 28843037Read ↗

The IWGT in vitro Mammalian Cell Gene Mutation (MCGM) assays working group-Introductory remarks & consensus statements.Semantic proximity Read ↗

The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene.Semantic proximity Read ↗

Does the 2-test in vitro genotoxicity battery of Ames plus in vitro micronucleus tests detect relevant substances that induce gene mutations in vivo?Semantic proximity Read ↗

Genotoxicity Assessment of Nanomaterials: Recommendations on Best Practices, Assays, and Methods.Semantic proximity Read ↗

Mammalian cell HPRT gene mutation assay: test methods.Semantic proximity Read ↗

High-throughput quantitative analysis with cell growth kinetic curves for low copy number mutant cells.Semantic proximity Read ↗

Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: a follow-up to an ECVAM workshop.Semantic proximity Read ↗

In Vitro Mouse Lymphoma Cell (L5178Y Tk+/- 3.7.2C) Forward Mutation Assay.Semantic proximity Read ↗

Bacterial mutation assays.Semantic proximity Read ↗

Bacterial mutagenicity screening in the pharmaceutical industry.Semantic proximity Read ↗

Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro.Semantic proximity Read ↗

In vitro and in vivo mammalian mutation assays support a nonmutagenic mechanism of carcinogenicity for hydrazine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.