Article
Chinese hamster ovary cell assays for mutation and chromosome damage: data from non-carcinogens.
Journal of applied toxicology : JAT - 1 Jun 1991
Oshiro Y, Piper C E, Balwierz P S, Soelter S G
Abstract excerpt
In vitro genotoxicity tests are employed to screen chemicals for their capability to cause various DNA and chromosomal alterations, and the results are often used to predict their potential for carcinogenicity. However, there is controversy regarding the apparent low specificity of some in vitro genotoxicity assays, which result in a high false positive rate. Since we use and rely upon in vitro assays for risk...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- CHO Cells
- Carcinogenicity Tests
- Cell Survival
- Chromosome Aberrations
- Cricetinae
- Cricetulus
- Cyclophosphamide
- DNA Damage
- Methylcholanthrene