Article
Poly(ethylene imine) nanocarriers do not induce mutations nor oxidative DNA damage in vitro in MutaMouse FE1 cells.
Molecular pharmaceutics - 6 Jun 2011
Beyerle Andrea, Long Alexandra S, White Paul A, Kissel Thomas, Stoeger Tobias
Abstract excerpt
Genotoxicity information on polymers used for gene delivery is scant, but of great concern, especially when developing polymeric nanocarriers as nonviral vector systems for cancer treatment. The genotoxicity of some engineered nanomaterials, e.g., metal oxides like ZnO, TiO₂, and CuO but also carbon based materials like carbon black or nanotubes, has commonly been related to oxidative stress, and subsequent...
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