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Article

Response of Lens Epithelial Cells to Injury: Role of Lumican in Epithelial-Mesenchymal Transition

25 Apr 2003

Abstract excerpt

PURPOSE: Lens epithelial cells (LECs) undergo epithelial-mesenchcymal transition (EMT) after injury and transform into myofibroblasts positive for alpha-smooth muscle actin (alphaSMA), an established marker of this process. Lumican is a keratan sulfate proteoglycan core protein. This study was conducted to examine whether human and mouse LECs express lumican after injury. To determine whether lumican may modulate...

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PMID: 12714648
DOI: 10.1167/iovs.02-1059

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