FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity.

doi:10.1111/jcmm.13030

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Article

FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity.

Journal of cellular and molecular medicine - 1 May 2017

Kubo Eri, Shibata Shinsuke, Shibata Teppei, Kiyokawa Etsuko, Sasaki Hiroshi, Singh Dhirendra P

Abstract excerpt

Transforming growth factor (TGF) β2 and fibroblast growth factor (FGF) 2 are involved in regulation of posterior capsule opacification (PCO) and other processes of epithelial-mesenchymal transition (EMT) such as cancer progression, wound healing and tissue fibrosis as well as normal embryonic development. We previously used an in vivo rodent PCO model to show the expression of tropomyosin (Tpm) 1/2 was aberrantly...

Topics

Actins
Animals
Biomarkers
Capsule Opacification
Cell Movement
Cell Shape
Epithelial Cells
Epithelial-Mesenchymal Transition
Fibroblast Growth Factor 2
Humans
Lens Capsule, Crystalline

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

MAP Kinase Signaling System

Mice, Inbred BALB C

Phenotype

RNA, Small Interfering

Transfection

Transforming Growth Factor beta2

Tropomyosin

Source

Open in PubMed Open full text

Identifiers

PMID: 27976512
DOI: 10.1111/jcmm.13030
PMCID: PMC5387175

Genes

FGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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