Article
Impaired skin wound healing in lumican-null mice.
The British journal of dermatology - 1 Dec 2010
Yeh J-T, Yeh L-K, Jung S-M, Chang T-J, Wu H-H, Shiu T-F, Liu C-Y, Kao W W-Y, Chu P-H
Abstract excerpt
BACKGROUND: Previous studies have demonstrated that the lack of lumican delayed corneal wound healing in lumican-null (Lum(-/-) ) mice. This defect is rescued by the addition of glycosylated lumican core protein to the injured corneas. OBJECTIVES: We examined the hypothesis that lumican is also required for the healing of cutaneous wounds using Lum(-/-) mice. METHODS: We demonstrated the basic thinner skin...
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