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Article

A furin-defective cell line is able to process correctly the gp160 of human immunodeficiency virus type 1.

Journal of virology - 1 Jun 1994

Ohnishi Y, Shioda T, Nakayama K, Iwata S, Gotoh B, Hamaguchi M, Nagai Y

Abstract excerpt

Furin, a subtilisin-like mammalian endoprotease, is thought to be responsible for the processing of many proprotein precursors of cellular and viral origin, including gp160 of human immunodeficiency virus type 1, which share the consensus processing site motif, Arg-X-Lys/Arg-Arg, for protease recognition (for reviews, see P. J. Barr, Cell 66:1-3, 1991, and Y. Nagai, Trends Microbiol. 1:81-87, 1993). To confirm...

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Identifiers

PMID: 8189547
DOI: 10.1128/JVI.68.6.4075-4079.1994
PMCID: PMC236921

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