Article
A furin-defective cell line is able to process correctly the gp160 of human immunodeficiency virus type 1.
Journal of virology - 1 Jun 1994
Ohnishi Y, Shioda T, Nakayama K, Iwata S, Gotoh B, Hamaguchi M, Nagai Y
Abstract excerpt
Furin, a subtilisin-like mammalian endoprotease, is thought to be responsible for the processing of many proprotein precursors of cellular and viral origin, including gp160 of human immunodeficiency virus type 1, which share the consensus processing site motif, Arg-X-Lys/Arg-Arg, for protease rec...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Cell Line
- Consensus Sequence
- Cricetinae
- Furin
- Gene Products, env
- HIV Envelope Protein gp160
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation
- Protein Precursors
- Protein Processing, Post-Translational
- Subtilisins