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Article

An essential role for ectodomain shedding in mammalian development.

Science (New York, N.Y.) - 13 Nov 1998

Peschon J J, Slack J L, Reddy P, Stocking K L, Sunnarborg S W, Lee D C, Russell W E, Castner B J, Johnson R S, Fitzner J N, Boyce R W, Nelson N, Kozlosky C J, Wolfson M F, Rauch C T, Cerretti D P, Paxton R J, March C J, Black R A

Abstract excerpt

The ectodomains of numerous proteins are released from cells by proteolysis to yield soluble intercellular regulators. The responsible protease, tumor necrosis factor-alpha converting enzyme (TACE), has been identified only in the case when tumor necrosis factor-alpha (TNFalpha) is released. Analyses of cells lacking this metalloproteinase-disintegrin revealed an expanded role for TACE in the processing of other...

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PMID: 9812885
DOI: 10.1126/science.282.5392.1281

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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An essential role for ectodomain shedding in mammalian development.PMID 9812885Read ↗

Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability.Semantic proximity Read ↗

The transmembrane domain of TACE regulates protein ectodomain shedding.Semantic proximity Read ↗

Active Metalloproteases of the A Disintegrin And Metalloprotease (ADAM) Family: Biological Function and StructureSemantic proximity Read ↗

Tumor necrosis factor-alpha converting enzyme.Semantic proximity Read ↗

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands.Semantic proximity Read ↗

TACE is required for fetal murine cardiac development and modeling.Semantic proximity Read ↗

Systemic Overexpression of TNFα-converting Enzyme Does Not Lead to Enhanced Shedding Activity In VivoSemantic proximity Read ↗

Emerging roles for ADAMTS5 during development and disease.Semantic proximity Read ↗

L-selectin: mechanisms and physiological significance of ectodomain cleavage.Semantic proximity Read ↗

Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR).Semantic proximity Read ↗

Ectodomain shedding of TGF‐α and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascadesSemantic proximity Read ↗

Pulmonary Hypoplasia in Mice Lacking Tumor Necrosis Factor-α Converting Enzyme Indicates an Indispensable Role for Cell Surface Protein Shedding during Embryonic Lung Branching MorphogenesisSemantic proximity Read ↗

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