Article
An essential role for ectodomain shedding in mammalian development.
Science (New York, N.Y.) - 13 Nov 1998
Peschon J J, Slack J L, Reddy P, Stocking K L, Sunnarborg S W, Lee D C, Russell W E, Castner B J, Johnson R S, Fitzner J N, Boyce R W, Nelson N, Kozlosky C J, Wolfson M F, Rauch C T, Cerretti D P, Paxton R J, March C J, Black R A
Abstract excerpt
The ectodomains of numerous proteins are released from cells by proteolysis to yield soluble intercellular regulators. The responsible protease, tumor necrosis factor-alpha converting enzyme (TACE), has been identified only in the case when tumor necrosis factor-alpha (TNFalpha) is released. Anal...
Topics
- ADAM Proteins
- ADAM17 Protein
- Amino Acid Sequence
- Animals
- Catalytic Domain
- Cell Membrane
- Cells, Cultured
- Crosses, Genetic
- Embryonic and Fetal Development
- L-Selectin
- Ligands
- Membrane Proteins
- Metalloendopeptidases
- Mice