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Article

Inactivating mutations block the tumor necrosis factor-alpha-converting enzyme in the early secretory pathway.

Biochemical and biophysical research communications - 20 Feb 2004

Villanueva de la Torre Teresa, Bech-Serra Joan J, Ruiz-Paz Soraya, Baselga Josep, Arribas Joaquín

Abstract excerpt

The ectodomain of different transmembrane molecules is released by a proteolytic event known as shedding. The metalloprotease disintegrin proTNF-alpha converting enzyme (TACE) is responsible for the shedding of various proteins, including protransforming growth factor-alpha (proTGF-alpha) and amyloid-beta precursor protein (APP). Inactive TACE accumulates in the early secretory pathway of cell mutants (M1 and M2)...

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Identifiers

PMID: 14751236
DOI: 10.1016/j.bbrc.2003.12.186

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inactivating mutations block the tumor necrosis factor-alpha-converting enzyme in the early secretory pathway.PMID 14751236Read ↗

Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain shedding.Semantic proximity Read ↗

Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR).Semantic proximity Read ↗

The transmembrane domain of TACE regulates protein ectodomain shedding.Semantic proximity Read ↗

Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability.Semantic proximity Read ↗

Chaperone-like properties of the prodomain of TNFalpha-converting enzyme (TACE) and the functional role of its cysteine switch.Semantic proximity Read ↗

Proteolytic processing of the serine protease matriptase-2: identification of the cleavage sites required for its autocatalytic release from the cell surface.Semantic proximity Read ↗

An essential role for ectodomain shedding in mammalian development.Semantic proximity Read ↗

The regulation of TACE catalytic function by its prodomain.Semantic proximity Read ↗

Tumor necrosis factor-alpha converting enzyme.Semantic proximity Read ↗

Proteolytic Shedding of Human Colony-Stimulating Factor 1 Receptor and its implication.Semantic proximity Read ↗

Systemic Overexpression of TNFα-converting Enzyme Does Not Lead to Enhanced Shedding Activity In VivoSemantic proximity Read ↗

ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after histidine 157Semantic proximity Read ↗

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