Article
Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors.
The Journal of biological chemistry - 10 May 1996
Arribas J, Coodly L, Vollmer P, Kishimoto T K, Rose-John S, Massagué J
Abstract excerpt
The extracellular domains of a diverse group of membrane proteins are shed in response to protein kinase C activators such as phorbol 12-myristate 13-acetate (PMA). The lack of sequence similarity in the cleavage sites suggests the involvement of many proteases of diverse specificity in this proc...
Topics
- Amyloid beta-Protein Precursor
- Animals
- Antigens, CD
- CHO Cells
- Cell Membrane
- Cricetinae
- Genetic Complementation Test
- Hydroxamic Acids
- Kinetics
- L-Selectin
- Membrane Proteins
- Metalloendopeptidases
- Mutagenesis
- Phenanthrolines
- Phenotype
- Protease Inhibitors
- Protein Precursors
- Receptors, Interleukin