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Article

Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability.

The Journal of biological chemistry - 12 Apr 2002

Sunnarborg Susan Wohler, Hinkle C Leann, Stevenson Mary, Russell William E, Raska Christina S, Peschon Jacques J, Castner Beverly J, Gerhart Mary J, Paxton Raymond J, Black Roy A, Lee David C

Abstract excerpt

We previously implicated tumor necrosis factor-alpha converting enzyme (TACE/ADAM17) in the processing of the integral membrane precursor to soluble transforming growth factor-alpha (TGF-alpha), pro-TGF-alpha. Here we examined TGF-alpha processing in a physiologically relevant cell model, primary keratinocytes, showing that cells lacking TACE activity shed dramatically less TGF-alpha as compared with wild-type...

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Source

Identifiers

PMID: 11823465
DOI: 10.1074/jbc.M112050200

Genes

EGF
EGFR
ADAM17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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