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Article

Subtype differences in pre-coupling of muscarinic acetylcholine receptors.

PloS one - 1 Jan 2011

Jakubík Jan, Janíčková Helena, Randáková Alena, El-Fakahany Esam E, Doležal Vladimír

Abstract excerpt

Based on the kinetics of interaction between a receptor and G-protein, a myriad of possibilities may result. Two extreme cases are represented by: 1/Collision coupling, where an agonist binds to the free receptor and then the agonist-receptor complex "collides" with the free G-protein. 2/Pre-coupling, where stable receptor/G-protein complexes exist in the absence of agonist. Pre-coupling plays an important role...

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Identifiers

PMID: 22110745
DOI: 10.1371/journal.pone.0027732
PMCID: PMC3218020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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