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Article

Loss of cap structure causes mitotic defect in Tetrahymena thermophila telomerase mutants.

Chromosoma - 1 Apr 2003

Petcherskaia Marina, McGuire Jennifer M, Pherson James M, Kirk Karen E

Abstract excerpt

Mutation of the telomeric repeat sequence has severe cellular consequences in a variety of systems. A Tetrahymena thermophila telomerase template mutant, ter1-43AA, displays an acute mitotic chromosome segregation defect. In the study described here we investigated the molecular basis for this lethality. Although cloned ter1-43AA macronuclear telomeres had long tracts of wild-type G4T2 repeats, they were capped...

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Identifiers

PMID: 12707780
DOI: 10.1007/s00412-003-0233-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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