Article
The telomere and telomerase: nucleic acid-protein complexes acting in a telomere homeostasis system. A review.
Biochemistry. Biokhimiia - 1 Nov 1997
Blackburn E H
Abstract excerpt
The tandemly repeated DNA sequence of telomeres is typically specified by the ribonucleoprotein enzyme telomerase. Telomerase copies part of its intrinsic RNA moiety to synthesize one strand of the telomeric repeat DNA Recent work, taken together with many observations over the past years, has led to the concept of a telomere homeostasis system. We have analyzed the interplay between two key physical components...
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