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Article

Block in anaphase chromosome separation caused by a telomerase template mutation.

Science (New York, N.Y.) - 7 Mar 1997

Kirk K E, Harmon B P, Reichardt I K, Sedat J W, Blackburn E H

Abstract excerpt

Telomeres are essential for chromosome stability, but their functions at specific cell-cycle stages are unknown. Telomeres are now shown to have a role in chromosome separation during mitosis. In telomeric DNA mutants of Tetrahymena thermophila, created by expression of a telomerase RNA with an altered template sequence, division of the germline nucleus was severely delayed or blocked in anaphase. The mutant...

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Share to Base Sequence
Share to Chromosomes
Share to DNA, Protozoan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Repetitive Sequences, Nucleic Acid

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Source

Identifiers

PMID: 9045613
DOI: 10.1126/science.275.5305.1478

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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