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Article

TIF1 Represses rDNA replication initiation, but promotes normal S phase progression and chromosome transmission in Tetrahymena.

Molecular biology of the cell - 1 Jun 2005

Morrison Tara L, Yakisich J Sebastian, Cassidy-Hanley Donna, Kapler Geoffrey M

Abstract excerpt

The non-ORC protein, TIF1, recognizes sequences in the Tetrahymena thermophila ribosomal DNA (rDNA) minichromosome that are required for origin activation. We show here that TIF1 represses rDNA origin firing, but is required for proper macronuclear S phase progression and division. TIF1 mutants exhibit an elongated macronuclear S phase and diminished rate of DNA replication. Despite this, replication of the rDNA...

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Source

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Identifiers

PMID: 15772155
DOI: 10.1091/mbc.e05-02-0107
PMCID: PMC1142411

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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