Article
Identification of an essential proximal sequence element in the promoter of the telomerase RNA gene of Tetrahymena thermophila.
Nucleic acids research - 1 Nov 1999
Hargrove B W, Bhattacharyya A, Domitrovich A M, Kapler G M, Kirk K, Shippen D E, Kunkel G R
Abstract excerpt
Telomerase is a ribonucleoprotein reverse transcriptase that synthesizes and maintains telomeric DNA. Studies of telomeres and telomerase are facilitated by the large number of linear DNA molecules found in ciliated protozoa, such as Tetrahymena thermophila. To examine the expression of telomerase, we investigated the transcription of the RNA polymerase III-directed gene encoding the RNA subunit (TER1) of this...
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