Article
Development of overt proteinuria in the Munich Wistar Frömter rat is suppressed by replacement of chromosome 6 in a consomic rat strain.
Journal of the American Society of Nephrology : JASN - 1 Jan 2007
Schulz Angela, Weiss Judith, Schlesener Maria, Hänsch Jonna, Wehland Markus, Wendt Norbert, Kossmehl Peter, Sietmann Anika, Grimm Daniela, Stoll Monika, Nyengaard Jens Randel, Kreutz Reinhold
Abstract excerpt
In a cross between the Munich Wistar Frömter (MWF) rat and spontaneously hypertensive rats (SHR), a major quantitative trait locus (QTL) was identified on rat chromosome 6 (RNO6) that demonstrated the strongest linkage to albuminuria among several QTL identified. The QTL represented the only locus that is linked to both early-onset albuminuria and increased renal interstitial fibrosis in adult animals. A consomic...
Topics
- Albuminuria
- Animals
- Animals, Congenic
- Base Sequence
- Chromosome Mapping
- Crosses, Genetic
- DNA Primers
- Kidney
- Male
- Phenotype
- Proteinuria
- Quantitative Trait Loci
- Rats