Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA repair and cancer: lessons from mutant mouse models.

Cancer science - 1 Feb 2004

Ishikawa Takatoshi, Zhang Samuel S-M, Qin Xiusheng, Takahashi Yoshihisa, Oda Hideaki, Nakatsuru Yoko, Ide Fumio

Abstract excerpt

DNA damage, if the repair process, especially nucleotide excision repair (NER), is compromised or the lesion is repaired by some other error-prone mechanism, causes mutation and ultimately contributes to neoplastic transformation. Impairment of components of the DNA damage response pathway (e.g.,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Xeroderma Pigmentosum Group A Protein
Share to Disease Models, Animal
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Genes, p53

Share to Mice, Mutant Strains

Share to Neoplasms

Share to O(6)-Methylguanine-DNA Methyltransferase

Source

Open in PubMed Open full text

Identifiers

PMID: 14965359
DOI: 10.1111/j.1349-7006.2004.tb03190.x
PMCID: PMC11158213

Genes

MGMT
XPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14965359-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA repair and cancer: lessons from mutant mouse models.PMID 14965359Read ↗

Nucleotide excision repair- and p53-deficient mouse models in cancer research.Semantic proximity Read ↗

Cancer predisposition associated with defective DNA repair: studies with mutant mouse strains.Semantic proximity Read ↗

p53 heterozygosity results in an increased 2-acetylaminofluorene-induced urinary bladder but not liver tumor response in DNA repair-deficient Xpa mice.Semantic proximity Read ↗

The role of nucleotide excision repair and loss of p53 in mutagenesis and carcinogenesis.Semantic proximity Read ↗

Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes.Semantic proximity Read ↗

Haploinsufficiency in mouse models of DNA repair deficiency: modifiers of penetrance.Semantic proximity Read ↗

Mesotheliomas in Genetically Engineered Mice Unravel Mechanism of Mesothelial Carcinogenesis.Semantic proximity Read ↗

Mouse models of XRCC1 DNA repair polymorphisms and cancer.Semantic proximity Read ↗

Sex and Alkyladenine DNA Glycosylase Expression are Key Susceptibility Factors for NDMA-induced Mutations, Toxicity, and CancerSemantic proximity Read ↗

Cancer predisposition in mutant mice defective in multiple genetic pathways: uncovering important genetic interactions.Semantic proximity Read ↗

DNA repair-deficient Xpa and Xpa/p53+/- knock-out mice: nature of the models.Semantic proximity Read ↗

TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.