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Article

Involvements of mitochondrial thioredoxin reductase (TrxR2) in cell proliferation.

Biochemical and biophysical research communications - 25 Apr 2003

Kim Mi-Ra, Chang Ho-Sung, Kim Byung-Hak, Kim Seongyong, Baek Suk-Hwan, Kim Jung Hye, Lee Seung-Rock, Kim Jae-Ryong

Abstract excerpt

Mammalian cells contain two forms of thioredoxin reductase (TrxR), cytosolic TrxR1 and mitochondrial TrxR2. To investigate the biological roles of TrxR2, we generated stable HeLa cell lines expressing a dominant negative form of TrxR2 (TrxR2DN) under the control of the tetracycline-off system. We observed that TrxR2DN-induced cells, following stimulation with EGF, produced more hydrogen peroxide than uninduced...

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Identifiers

PMID: 12705894
DOI: 10.1016/s0006-291x(03)00547-3

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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