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Article

Mitochondrial ROS and radiation induced transformation in mouse embryonic fibroblasts.

Cancer biology & therapy - 1 Oct 2009

Du Changbin, Gao Zhen, Venkatesha Venkatasubbaiah A, Kalen Amanda L, Chaudhuri Leena, Spitz Douglas R, Cullen Joseph J, Oberley Larry W, Goswami Prabhat C

Abstract excerpt

Manganese superoxide dismutase (SOD2) is a nuclear encoded and mitochondria localized antioxidant enzyme that converts mitochondria derived superoxide to hydrogen peroxide. This study investigates the hypothesis that mitochondria derived reactive oxygen species (ROS) regulate ionizing radiation (IR) induced transformation in normal cells. Mouse embryonic fibroblasts (MEFs) with wild type SOD2 (+/+), heterozygous...

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Share to Cell Transformation, Neoplastic
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glutathione

Share to Immunoblotting

Share to Micronuclei, Chromosome-Defective

Share to Radiation, Ionizing

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Source

Open in PubMed Open full text

Identifiers

PMID: 19738419
DOI: 10.4161/cbt.8.20.9648
PMCID: PMC2795790

Genes

SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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