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Mitochondrial hTERT exacerbates free‐radical‐mediated mtDNA damage

24 Sept 2004

Abstract excerpt

Telomerase is often re-activated in human cancers and is widely used to immortalize cells in culture. In addition to the maintenance of telomeres, telomerase has been implicated in cell proliferation, genomic instability and apoptosis. Here we show that human telomerase reverse transcriptase (hTERT) is targeted to the mitochondria by an N-terminal leader sequence, and that mitochondrial extracts contain...

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Share to Mitochondrial Function and Pathology
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PMID: 15569357
DOI: 10.1111/j.1474-9728.2004.00124.x

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