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Article

Oxidation of thioredoxin reductase in HeLa cells stimulated with tumor necrosis factor-alpha.

FEBS letters - 4 Jun 2004

Kim Jae-Ryong, Lee Seon-Min, Cho Seung-Hyun, Kim Jung-Hyun, Kim Byung-Hak, Kwon Jaeyul, Choi Cheol Yong, Kim Yeong-Dae, Lee Seung-Rock

Abstract excerpt

Stimulation of cells with tumor necrosis factor-alpha (TNF-alpha) results in the increase in generation of H(2)O(2) in mitochondria that leads to apoptosis. The effect of H(2)O(2) produced by TNF-alpha on the redox status of selenocysteine (SeCys) residue essential for mitochondrial thioredoxin reductase (TrxR2) was investigated in HeLa cells. TNF-alpha caused accumulation of oxidized TrxR2 with a thioselenide...

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Source

Identifiers

PMID: 15178321
DOI: 10.1016/j.febslet.2004.04.055

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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