Article
Transfection with human thioredoxin increases cell proliferation and a dominant-negative mutant thioredoxin reverses the transformed phenotype of human breast cancer cells.
Cancer research - 15 Dec 1996
Gallegos A, Gasdaska J R, Taylor C W, Paine-Murrieta G D, Goodman D, Gasdaska P Y, Berggren M, Briehl M M, Powis G
Abstract excerpt
Thioredoxin, a redox protein with growth factor activity that modulates the activity of several proteins important for cell growth, has been reported to be overexpressed in a number of human primary cancers. In the present study, the effects of stably transfecting mouse NIH 3T3 cells and MCF-7 hu...
Topics
- 3T3 Cells
- Animals
- Breast Neoplasms
- Cell Division
- Cell Transformation, Neoplastic
- Cysteine
- Genetic Vectors
- Humans
- Mice
- Mutation
- Neoplasm Proteins
- Peptide Fragments
- Phenotype
- Serine
- Thioredoxins
- Transfection
- Tumor Cells, Cultured