Article
Transfection with human thioredoxin increases cell proliferation and a dominant-negative mutant thioredoxin reverses the transformed phenotype of human breast cancer cells.
Cancer research - 15 Dec 1996
Gallegos A, Gasdaska J R, Taylor C W, Paine-Murrieta G D, Goodman D, Gasdaska P Y, Berggren M, Briehl M M, Powis G
Abstract excerpt
Thioredoxin, a redox protein with growth factor activity that modulates the activity of several proteins important for cell growth, has been reported to be overexpressed in a number of human primary cancers. In the present study, the effects of stably transfecting mouse NIH 3T3 cells and MCF-7 human breast cancer cells with cDNA for wild-type human thioredoxin or a redox-inactive mutant thioredoxin,...
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