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Article

Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication.

PloS one - 31 Oct 2007

Yoo Min-Hyuk, Xu Xue-Ming, Carlson Bradley A, Patterson Andrew D, Gladyshev Vadim N, Hatfield Dolph L

Abstract excerpt

Thioredoxin reductase 1 (TR1) is a major redox regulator in mammalian cells. As an important antioxidant selenoprotein, TR1 is thought to participate in cancer prevention, but is also known to be over-expressed in many cancer cells. Numerous cancer drugs inhibit TR1, and this protein has been proposed as a target for cancer therapy. We previously reported that reduction of TR1 levels in cancer cells reversed many...

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Identifiers

PMID: 17971875
DOI: 10.1371/journal.pone.0001112
PMCID: PMC2040202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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