Regulation of the mammalian selenoprotein thioredoxin reductase 1 in relation to cellular phenotype, growth, and signaling events.

doi:10.1089/152308604771978336

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Article

Regulation of the mammalian selenoprotein thioredoxin reductase 1 in relation to cellular phenotype, growth, and signaling events.

Antioxidants & redox signaling - 1 Feb 2004

Rundlöf Anna-Klara, Arnér Elias S J

Abstract excerpt

Reactive oxygen species (ROS) are generated as toxic by-products of aerobic metabolism, but are also essential biomolecules in cell signaling. The thioredoxin (Trx) system is a major enzymatic system modulating ROS levels and is important for redox regulation of cellular function. It consists of Trx and thioredoxin reductase (TrxR), which reduces Trx using NADPH. Most, if not all, of the functions of Trx depend...

Topics

Animals
Cell Division
Gene Expression Regulation, Enzymologic
Humans
Oxidation-Reduction
Phenotype
Proteins
Reactive Oxygen Species
Selenoproteins
Signal Transduction
Thioredoxin Reductase 1
Thioredoxin-Disulfide Reductase
Thioredoxins

Source

Open in PubMed

Identifiers

PMID: 14980055
DOI: 10.1089/152308604771978336

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