Article
Induction of apoptosis by the overexpression of an alternative splicing variant of mitochondrial thioredoxin reductase.
Free radical biology & medicine - 15 Dec 2005
Chang En Young, Son Seong-Kweon, Ko Hyun Sook, Baek Suk-Hwan, Kim Jung Hye, Kim Jae-Ryong
Abstract excerpt
Mammalian cells harbor two forms of thioredoxin reductase (TrxR), cytosolic TrxR1 and mitochondrial TrxR2, both of which are involved in the redox regulation of cell growth and apoptosis. Furthermore, several alternative splicing variants of TrxR1 and TrxR2 have been identified. However, little remains known with regard to their functions in cells. Here, we report an alternative splicing variant of TrxR2...
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