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Article

Thioredoxin-1 phosphorylated at T100 is needed for its anti-apoptotic activity in HepG2 cancer cells.

Life sciences - 14 Aug 2010

Chen Xiaoping, Tang Wenxin, Liu Shan, Yu Longjiang, Chen Zhengwang

Abstract excerpt

AIMS: Thioredoxin-1 (Trx) is an important protein involved in the regulation of apoptosis and in enhancing drug resistance in cancer cells. Threonine100 (T100) of Trx was reported to be phosphorylated; however, the role of this phosphorylation in regulating activity remains unresolved. We explored whether and how the phosphorylation of Trx is involved in drug resistance in cancer cells. MAIN METHODS: The levels...

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Identifiers

PMID: 20619274
DOI: 10.1016/j.lfs.2010.06.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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