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Article

Pp60c-src mediates ERK activation/nuclear localization and PAI-1 gene expression in response to cellular deformation.

Journal of cellular physiology - 1 Jun 2003

Samarakoon Rohan, Higgins Paul J

Abstract excerpt

Release of transcellular tension upon disruption of actin stress fibers with cytochalasin D (CD) and associated changes in cell morphology are reflected in the rapid transcription of "deformation-responsive" genes. For certain genes (e.g., urokinase plasminogen activator and its type-1 inhibitor PAI-1), de novo mRNA synthesis appears to require cell shape-dependent activation of the MAP kinases ERK1/2. ERK...

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PMID: 12704650
DOI: 10.1002/jcp.10247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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