Article
pp60c-src is a positive regulator of growth factor-induced cell scattering in a rat bladder carcinoma cell line.
The Journal of cell biology - 1 Nov 1995
Rodier J M, Vallés A M, Denoyelle M, Thiery J P, Boyer B
Abstract excerpt
The NBT-II rat carcinoma cell line exhibits two mutually exclusive responses to FGF-1 and EGF, entering mitosis at cell confluency while undergoing an epithelium-to-mesenchyme transition (EMT) when cultured at subconfluency. EMT is characterized by acquisition of cell motility, modifications of cell morphology, and cell dissociation correlating with the loss of desmosomes from cellular cortex. The pleiotropic...
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