Article
Persistent induction of cyclooxygenase in p60v-src-transformed 3T3 fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 1990
Han J W, Sadowski H, Young D A, Macara I G
Abstract excerpt
A BALB/c 3T3 cell line infected with the temperature-sensitive Rous sarcoma virus strain LA90 has been used to investigate early, p60v-src-dependent changes in gene expression (protein synthesis). Giant two-dimensional electrophoresis, which can resolve greater than 3000 polypeptides from [35S]me...
Topics
- Animals
- Avian Sarcoma Viruses
- Cell Line
- Cell Transformation, Neoplastic
- Cells, Cultured
- Dexamethasone
- Enzyme Induction
- Kinetics
- Methionine
- Mice
- Mutation
- Oncogene Protein pp60(v-src)
- Platelet-Derived Growth Factor
- Prostaglandin-Endoperoxide Synthases
- Protein Kinase C
- Protein-Tyrosine Kinases
- Temperature
- Tetradecanoylphorbol Acetate