Article
Mismatch repair: mechanisms and relationship to cancer susceptibility.
Trends in biochemical sciences - 1 Oct 1995
Kolodner R D
Abstract excerpt
DNA mismatch-repair systems exist that repair mispaired bases formed during DNA replication, genetic recombination and as a result of damage to DNA. Some components of these systems are conserved in prokaryotes and eukaryotes. Genetic defects in mismatch-repair genes play an important role in com...
Topics
- Adaptor Proteins, Signal Transducing
- Adenosine Triphosphatases
- Bacterial Proteins
- Base Composition
- Carrier Proteins
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Repair
- Escherichia coli
- Escherichia coli Proteins
- Fungal Proteins
- Genetic Predisposition to Disease
- Humans
- Models, Genetic
- MutL Protein Homolog 1
- MutL Proteins
- Mutation
- Neoplasm Proteins
- Neoplasms