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Article

Regulation of insulin-like growth factor receptors by Ubiquilin1

23 Oct 2017

Abstract excerpt

Insulin-like growth factor-1 receptor (IGF1R) is a receptor tyrosine kinase that mediates growth, proliferation and survival. Dysregulation of IGF pathway contributes to the initiation, progression and metastasis of cancer and is also involved in diseases of glucose metabolism, such as diabetes. We have identified Ubiquilin1 (UBQLN1) as a novel interaction partner of IGF1R, IGF2R and insulin receptor (INSR)....

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Share to Growth Hormone and Insulin-like Growth Factors
Share to Metabolism, Diabetes, and Cancer
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PMID: 29054976
DOI: 10.1042/bcj20170620

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