Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation.

The Journal of biological chemistry - 18 Jun 2004

Murdaca Joseph, Treins Caroline, Monthouël-Kartmann Marie-Noëlle, Pontier-Bres Rodolphe, Kumar Sharad, Van Obberghen Emmanuel, Giorgetti-Peraldi Sophie

Abstract excerpt

One of the cellular mechanisms used to prevent continuous and enhanced activation in response to growth factors is the internalization and degradation of their receptors. Little is known about the molecular mechanisms involved in vascular endothelial growth factor receptor-2 (VEGF-R2) degradation. In a previous work, we have shown that the adaptor protein Grb10 is a positive regulator of the VEGF signaling...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Northern
Share to Endocytosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endosomal Sorting Complexes Required for Transport

Share to Endothelium, Vascular

Share to Nedd4 Ubiquitin Protein Ligases

Share to Precipitin Tests

Share to Ubiquitin

Share to Vascular Endothelial Growth Factor Receptor-2

Source

Identifiers

PMID: 15060076
DOI: 10.1074/jbc.M311802200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation.PMID 15060076Read ↗

Molecular targeting of growth factor receptor-bound 2 (Grb2) as an anti-cancer strategySemantic proximity Read ↗

The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor.Semantic proximity Read ↗

VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysisSemantic proximity Read ↗

Zebrafish G protein gamma2 is required for VEGF signaling during angiogenesis.Semantic proximity Read ↗

A mutated soluble neuropilin-2 B domain antagonizes vascular endothelial growth factor bioactivity and inhibits tumor progression.Semantic proximity Read ↗

ErbB2 degradation mediated by the co-chaperone protein CHIP.Semantic proximity Read ↗

The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.Semantic proximity Read ↗

Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2.Semantic proximity Read ↗

Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.Semantic proximity Read ↗

Regulatory role of dynamin-2 in VEGFR-2/KDR-mediated endothelial signaling.Semantic proximity Read ↗

Sprouty2 binds Grb2 at two different proline-rich regions, and the mechanism of ERK inhibition is independent of this interaction.Semantic proximity Read ↗

The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.