Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor.

doi:10.1093/emboj/18.1.28

Back to search

Article

Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor.

The EMBO journal - 4 Jan 1999

Govers R, ten Broeke T, van Kerkhof P, Schwartz A L, Strous G J

Abstract excerpt

In addition to its role in selective protein degradation, the conjugation of ubiquitin to proteins has also been implicated in the internalization of plasma membrane proteins, including the alpha-factor receptor Ste2p, uracil permease Fur4p, epithelial sodium channel ENaC and the growth hormone r...

Topics

Amino Acid Sequence
Animals
Binding Sites
CHO Cells
Cricetinae
Endocytosis
Growth Hormone
Ligands
Lysine
Mutation
Rabbits
Receptors, Somatotropin
Recombinant Proteins
Transfection
Ubiquitins

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.