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Article

PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons.

Stem cell reports - 14 Feb 2017

Wang Liheng, Sui Lina, Panigrahi Sunil K, Meece Kana, Xin Yurong, Kim Jinrang, Gromada Jesper, Doege Claudia A, Wardlaw Sharon L, Egli Dieter, Leibel Rudolph L

Abstract excerpt

We recently developed a technique for generating hypothalamic neurons from human pluripotent stem cells. Here, as proof of principle, we examine the use of these cells in modeling of a monogenic form of severe obesity: PCSK1 deficiency. The cognate enzyme, PC1/3, processes many prohormones in neuroendocrine and other tissues. We generated PCSK1 (PC1/3)-deficient human embryonic stem cell (hESC) lines using both...

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Identifiers

PMID: 28132887
DOI: 10.1016/j.stemcr.2016.12.021
PMCID: PMC5312251

Genes

POMC
PCSK1
PRCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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