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Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects

26 Jul 2002

Abstract excerpt

The subtilisin-like proprotein convertases PC1/3 (SPC3) and PC2 (SPC2) are believed to be the major endoproteolytic processing enzymes of the regulated secretory pathway. They are expressed together or separately in neuroendocrine cells throughout the brain and dispersed endocrine system in both vertebrates and invertebrates. Disruption of the gene-encoding mouse PC1/3 has now been accomplished and results in a...

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PMID: 12145326
DOI: 10.1073/pnas.162352599

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